1 the genetic challenge of coronary artery disease
Báo cáo y học: "Role of STAT4 polymorphisms in systemic lupus erythematosus in a Japanese population: a case-control association study of the STAT1-STAT4 region" pot
Ngày tải lên :
09/08/2014, 13:22
... a complex disease characterized by autoantibody production and involvement of multiple organs, including kidneys Both genetic and environmental factors contribute to the development of SLE [1] ... [16] Moreover, the requirement of STAT4 in IL-23-induced IL-17 production has been suggested [17] Two isoforms of STAT4, STAT4α and STAT4β, are known [18] Expression of STAT4β, lacking the transactivation ... University of Tsukuba, and the University of Tokyo All patients and healthy controls were unrelated Japanese per- Page of (page number not for citation purposes) sons living in the central part of Japan...
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Báo cáo y học: "TLR7 single-nucleotide polymorphisms in the 3’ untranslated region and intron 2 independently contribute to systemic lupus erythematosus in Japanese women: a case-control association study" ppsx
Ngày tải lên :
12/08/2014, 15:22
... significant association of the haplotype containing all of the three SLE risk alleles, but not of the other haplotypes All of these results support the possibility that the possession of both the 3’UTR ... allele of the 3’UTR SNP and elevated expression of TLR7 [7], evidence for the association of the intronic SNPs with levels of TLR7 mRNA was not observed, and therefore the molecular mechanism of ... the basis of the HapMap Phase II JPT (Japanese in Tokyo) data obtained from the HapMap database [9] with the criteria of minor allele frequency >0.1 and an r2 threshold of 0.9 Genotyping of the...
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Báo cáo y học: "Lack of association of a variable number of aspartic acid residues in the asporin gene with osteoarthritis susceptibility: case-control studies in Spanish Caucasians" potx
Ngày tải lên :
09/08/2014, 07:20
... restricted analysis to the 35.5% of controls (294/828 donors, 115 women and 179 men) that did not show clinical manifestations of OA (absence of chronic pain or restriction of mobility in the two years ... number of alleles (%) Page of (page number not for citation purposes) Available online http://arthritis-research.com/content/8/3/R55 Table Comparisons of the D14 and D13 allelic frequencies of the ... implemented in the T2 option of the Clump software that follows a Monte Carlo approach [12] Post-hoc power was determined with the GPower software [13] for each comparison of the D14 and D13 allelic...
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Báo cáo y học: "Association of single-nucleotide polymorphisms in RHOB and TXNDC3 with knee osteoarthritis susceptibility: two case-control studies in East Asian populations and a meta-analysis" docx
Ngày tải lên :
09/08/2014, 10:23
... grades of or higher were included More than 70% of patients had a Kellgren-Lawrence score of or None of the control individuals had ever exhibited any signs or symptoms of arthritis or joint diseases ... ethnical committees of the Medical School of Nanjing University, and single nucleotide Page of (page number not for citation purposes) polymorphism (SNP) Research Center of RIKEN, and informed ... definite signs and symptoms of OA but also had radiographic evidence of OA All patients had pain with rest and/or night pain over 5month period Patients with knee diseases such as inflammatory,...
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Báo cáo y học: "Association of a single nucleotide polymorphism in growth differentiate factor 5 with congenital dysplasia of the hip: a case-control study" ppt
Ngày tải lên :
09/08/2014, 13:22
... The severity of CDH was defined from mild instability of the femoral head with slight capsular laxity, to moderate lateral displacement of the femoral head, without loss of contact of the head ... and congenital dislocation of the hip J Bone Joint Surg Br 1964, 46:40-45 Woolf CM, Koehn JH, Coleman SS: Congenital hip disease in Utah: the influence of genetic and nongenetic factors Am J Hum ... transcriptional activity of GDF5 in vitro and in vivo [20,21] Reduced expression of GDF5 would decrease the Table Genotype and allele frequencies of C/T transition SNP (rs143383) of the GDF5 gene in...
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Báo cáo y học: "Association between occupational exposure to mineral oil and rheumatoid arthritis: results from the Swedish EIRA case–control study" docx
Ngày tải lên :
09/08/2014, 07:20
... Results Of a total of 1,419 cases in this study, 1,012 were women and 407 were men (mean age at inclusion of 50 and 53 years, respectively) A total 65.5% of the female cases and 66.3% of the male ... branch of industry during the period of the stated exposure to mineral oils The industrial hygienist was blinded with regard to the disease status of the individuals According to the result of this ... knowledge of molecular pathogenesis and targeted therapies gained in different animal systems to develop a better understanding of both pathogenesis and treatment of relevant subgroups of the human disease...
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Báo cáo y học: "Association of functional variants of PTPN22 and tp53 in psoriatic arthritis: a case-control study" docx
Ngày tải lên :
09/08/2014, 07:20
... per cent of the PsA patients had polyarticular disease, 40% had oligoarticular disease and 2.9% had isolated spondyloarthritis Of the 238 PsA patients genotyped for the R620W variant of PTPN22 ... of the study was 49.7 years The mean age at onset of psoriasis was 29.3 years (standard deviation 14.2 years) and the mean age at onset of PsA was 38.1 years (standard deviation 11.0 years) Of ... amplification of the SNP site was carried out using the MassExtend primer and involved the use of specific d/ddNTP termination mixes, which were also determined using MassARRAY assay design software...
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Báo cáo y học: "Association of the microsatellite in the 3'''' untranslated region of the CD154 gene with rheumatoid arthritis in females from a Spanish cohort: a case-control study" ppsx
Ngày tải lên :
09/08/2014, 10:21
... process and common immunogenetic mechanisms underlying both autoimmune diseases, thus being in agreement with the hypothesis of the 'common genetic origin' of autoimmune diseases [55,56] contribute ... Association of CD154 with RA is independent of HLADRB1 and HLA-DQB1 Epidemiological studies show a strong association of MHC region with disease predisposition, being related to the presence of 'shared ... expected, the half-life of the 24CAs mRNAs was higher than that of the rest of the alleles after and 24 hours of anti-CD3 stimulation As shown in Figure 2a, scattering of the data in the non-24CAs...
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Báo cáo y học: "Association of MICA with rheumatoid arthritis independent of known HLA-DRB1 risk alleles in a family-based and a case control study" pps
Ngày tải lên :
09/08/2014, 14:20
... elucidate these genetic factors to better understand the disease However, even after the advent of genome-wide association studies, only somewhat more than half of the estimated genetic risk for ... increase of the model's likelihood that includes polymorphism MICA (that is, an LRT P value of less than 0.05) indicates an association of the MICA polymorphism independent of the known association of ... undertransmission of MICA-250A within all data of all families (OR 0.48, 95% CI 0.25 to 0.91, P = 0.02, Fisher exact test) Discussion The aim of this study was to analyze the association of polymorphisms of...
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Báo cáo y học: "Association of the T allele of an intronic single nucleotide polymorphism in the colony stimulating factor 1 receptor with Crohn''''s disease: a case-control study" ppt
Ngày tải lên :
11/08/2014, 10:23
... bowel disease remain to be investigated further Studies of the prevalence of NOD2 polymorphisms in patients with Crohn's disease point to a subset of patients with ileal and fibrostenotic disease ... 2004, Results Association of the T allele of the A2033T SNP with Crohn's disease especially in patients of Acadian descent A SNP (A2033T) was detected in the eleventh intron of the CSF1R gene that ... rates of the T allele in non-Acadian patients with Crohn's disease to those of non-Acadian controls (Table 4) In this analysis, patients with Crohn's disease still had significantly higher rates of...
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báo cáo khoa học: " The association of aggressive and chronic periodontitis with systemic manifestations and dental anomalies in a jordanian population: a case control study" pdf
Ngày tải lên :
11/08/2014, 20:20
... out of a total of 100 Percentage out of a total of 81 Percentage out of a total of 81 CP P-values Ababneh et al Head & Face Medicine 2010, 6:30 http://www.head-face-med.com/content/6/1/30 Page of ... at all a great deal of the time a lot of the time from time to time but not too often only occasionally not at all not often sometimes most of the time definitely usually not often not at all nearly ... ≥11 (Definite) Total Mean (± SD) 68 (68) 51 (63) 67 (83) d o.11 b c Out of total of 100 Out of a total of 81 Out of a total of 81 e 23 (23) 21 (26) 10 (12) 0.001 (9) (11) (5) 0.22f 100 (100) 81...
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báo cáo khoa học:" Lack of association between celiac disease and dental enamel hypoplasia in a case-control study from an Italian central region" pdf
Ngày tải lên :
11/08/2014, 23:22
... [Importance of oral signs in the diagnosis of atypical forms of celiac disease] Recenti Prog Med 2004, 95(10):482-490 Rasmusson CG, Eriksson MA: Celiac disease and mineralisation disturbances of permanent ... literature are often controversial, probably because of different geographical origin of patients studied and lack of adequate controls Finally, no studies have been performed, in CD patients of a Central ... epidemiology data showed the prevalence of CD to approach 1% of the general population [31-34] However, the clinical presentation of CD seems to differ from As abnormalities of the oral cavity have been...
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Báo cáo y học: "Association between occupation and knee and hip replacement due to osteoarthritis: a case-control study" doc
Ngày tải lên :
12/08/2014, 14:21
... verified diagnosis of OA, over 60 years of age at the time of surgery and having adequately answered the study questionnaire This left us Page of with 1,408 participating index cases of which 576 were ... 18:1587-1592 Croft P, Coggon D, Cruddas M, Cooper C: Osteoarthritis of the hip: an occupational disease in farmers BMJ 1992, 304:1269-1272 Croft P, Cooper C, Wickham C, Coggon D: Osteoarthritis of the ... from the same genetic pool Furthermore, we explored the inheritance of different professions within the cohort Materials and methods The study was approved by the Ethics Committee of Akureyri Central...
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Báo cáo y học: "Association of the D repeat polymorphism in the ASPN gene with developmental dysplasia of the hip: a case-control study in Han Chinese" potx
Ngày tải lên :
12/08/2014, 15:22
... Severity of DDH was defined from mild instability of the femoral head with slight capsular laxity, through moderate lateral displacement of the femoral head, without loss of contact of the head ... http://arthritis-research.com/content/13/1/R27 Page of Table Allelic frequency of the D-repeat polymorphism of ASPN in DDH in a Han Chinese population Group No of subject No of allele (%) D11 D12 D13 D14 D15 D16 ... dislocation of Page of the femoral head from the acetabulum [32] Control subjects were identified by detailed inquiry of history and physical examination, and they never had any history or symptoms of...
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Báo cáo y học: "Attributable mortality of Acinetobacter baumannii infections in critically ill patients: a systematic review of matched cohort and case-control studies" doc
Ngày tải lên :
12/08/2014, 23:23
... morbidity of patients with acquisition of or infection with Page of Characteristics and outcomes of matched cases and controls (patients infected and non-infected with A baumannii) Reference Site of ... (2) sex; (3) APACHE II; (4) date of admission; (5) primary diagnosis of ICU admission; (6) LOS in the ICU at least as long as that of the case before isolation of Ab; (7) Mechanical ventilation ... http://ccforum.com/content/10/2/R48 Table Table Comparison of patients with acquisition of A baumannii with matched controls Reference Site of infection; patients and setting Cases Controls Matching of controls to cases Colonization...
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THE VALUE OF RE USING PRIOR NESTED CASE CONTROL DATA IN NEW STUDIES WITH DIFFERENT OUTCOME
Ngày tải lên :
12/10/2015, 17:36
... each of the nested case-control study includes all cases of the disease of interest in the cohort, the probability of being selected into one NCC study is for those who develop the disease of interest ... here We assume the cohort consists of N individuals and the hazard functions of the two diseases (we denote the disease in the first study as A and the disease of interest in the current or second ... of the probability of inclusion in either study We also express the contribution of prior controls to the new study in terms of “effective number of controls” Based on this effective number of...
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Báo cáo y học: "Comparative study of control selection in a national population -based case-control study: Estimating risk of smoking on cancer deaths in Chinese men"
Ngày tải lên :
26/10/2012, 09:48
... consistent pattern of the effect of smoking on risk of cancer deaths TABLE Characteristics of cases and two control groups: Population-based case-control study of smoking on risk of cancer deaths ... between male living spouses of women who died of any cause and those spouses of women who died of some other causes other than smoking related causes The prevalence of smoking were 57.1% and 57.8%, ... 3.3%), nervous system diseases (320–359, 3.1%), digestive system diseases (520–579, 27.5%), genitourinary system diseases (580–608, 10.0%), musculoskeletal and connective tissue diseases (710–739,...
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Breast cancer risk in relation to occupations with exposure to carcinogens and endocrine disruptors: a Canadian case–control study pptx
Ngày tải lên :
06/03/2014, 02:21
... study can be explained by the current level of understanding of the impact of EDC exposures on receptor status, they are indicative of the benefit of occupational investigations with more rigorous ... Results Of 1,553 breast cancer cases referred, 160 were ineligible and 222 were unable to be reached Of the remainder, 165 declined, leaving 1006 cases for a participation rate of 86% Of 3,662 ... estimated to increase the odds of breast cancer by percent Inclusion of terms for total employment duration (lifetime employment as of study age) and the square of that term, produced a better...
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Occupation and Breast Cancer: A Canadian Case–Control Study docx
Ngày tải lên :
06/03/2014, 02:21
... Missing age of controls = 58.64); education level; annual household income; body mass index; number of pregnancies; years of oral contraceptive use; months of breast feeding; years of cigarette ... 766 ANNALS NEW YORK ACADEMY OF SCIENCES to better understand the significance of timing of exposure in terms of cancer risk KEYWORDS: breast cancer; occupation; environment; ... response rate of cases (99%) versus controls (52%) raising the issue of possible recruitment or selection bias Steps had been taken, however, to minimize the risk of such bias Selection of controls...
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